Profiles of Isoniazid and Rifampicin drug resistance conferring mutations in Mycobacterium tuberculosis among new and previously treated pulmonary tuberculosis cases from Kisumu County, Kenya

Mycobacterium tuberculosis infection is one of the leading causes mortality and morbidity in developing countries drug resistance remains a challenge. Drug hastened by point mutations bacilli genome their frequencies vary geographically hence need to understand regional specific patterns for early detection mutant strains. In this cross sectional study, Sputum samples from pulmonary clinical suspects were collected detect that confers Isoniazid rifampicin anti-anti drugs. Detection was done using GenoType MTBDRplus. Out sample 256 Tuberculosis suspected cases, 145 confirmed out which 32 (22%) new (TB) cases 113(78%) retreatment. The total isoniazid 9(6.2%), 2(6.3%) 7(6.3%) retreatment cases. Multi Resistance (MDR) 2(1.8%) all Rifampicin 7(4.8%), 1 (3.1%) case 6(5.3%) MDR among Resistance(RR) 28.6%. Low resilient strains had changes katG gene resulting nucleotide change A G C C. Four resistant isolates showed at rpoB with T single isolate displayed mutation G. Same different patients same facility might be an indication local transmission greater variability observed HIV positive are possibilities acquired during treatment courses repeated administration anti-TB